CHICAGO CYANIDE MURDERS A CASE STUDY IN CELLULAR RESPIRATION ANSWERS

This discussion can be omitted if time is limited. Add this document to saved. It has a bilayer of phospholipids and embedded proteins. The proteins in the membrane pass electrons from one to the other, this is known as the electron transport chain. The reason for the hypoxia is not always clear at the first examination. At the end of the electron transport chain, Cytochrome C passes the electron to its final acceptor, oxygen. Investigators found that all of the victims had taken an extra strength Tylenol hours before their deaths.

On further investigation, it was shown that the tissues had major mitochondrial damage. Oxygen then binds with proteins to create water. An ambulance rushed the girl to a nearby hospital, where she was pronounced dead. What additional information would you need to determine if they are connected? Students discuss the effect of cyanide binding on the ETC and why this would lead to the deaths of the individuals ingesting this poison. Adam Janus, a postal worker in another Chicago suburb also died unexpectedly, though originally it was thought he had suffered from a heart attack.

Would artificial respiration or oxygenation have saved these people?

Chicago Cyanide Murders: A Case Study in Cellular Respiration

What is causing these people to die? They suspected that someone had tampered with the medication. At the end of the electron transport chain, cytochrome C passes the electron to Complex IV and then to its final murcers, oxygen. The passing of these electrons allows ATP to be generated. It seems like a simple question, everyone knows you need to breathe to live.

Chicago Cyanide Murders by Tiagin Mijin on Prezi

While his family gathered to mourn their loss, his brother and sister became ill and later died. Any opinions, findings and conclusions, or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Science Foundation.

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Were the levels higher or lower anawers normal? Why or why not?

What additional information would you need to determine if they are connected? It could also be used in any course where students are learning a basic understanding of the cellular respiration pathways; however, it is not advanced enough for use in upper level courses without modification.

Case Studies with Quantitative Reasoning in Biology. In September ofMary Kellerman gave her 12 year old daughter a painkiller when she awoke during the night complaining of a sore throat. The victims of the cyanide poisoning all had high levels of oxygen in their blood, but the poison was interfering with how the cells use that oxygen.

Part 2: Chicago Cyanide Murders- A Case Study in Cellular Respiration

The case was developed for use in an introductory biology course taken by both science majors and nonmajors. This process is continuous in cells, with ATP constantly being generated and oxygen being used as the final electron acceptor.

Given what you know about ATP and cellular respiration, explain why cyanide is so fast acting. Cyanide acts very quickly, often killing within minutes of ingestion and authorities were slow to identify the cause of the deaths. Upload document Create flashcards.

Chicago Cyanide Murders: A Case Study in Cellular Respiration

It presents information about the patients’ levels of different metabolites important during cellular respiration. Develop a hypothesis about which pathway may be affected on the basis of these abnormalities. Recalling your knowledge of the function of organelles, what function of the cells was interrupted in these patients? Subcellular metabolite analysis Detailed analysis of the damaged cells showed that ATP levels in the mitochondria were very low.

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In the days that followed, three more unexplained deaths occurred in nearby Chicago suburbs.

Part I introduces the case and gets students to think epidemiologically about the information they receive. Cyanide is an extremely fast acting poison. In the past 5 days, seven people have died, murder with similar symptoms.

chicago cyanide murders a case study in cellular respiration answers

You might be surprised to learn that it directly interferes with cellular respiration that occurs in the mitochondria. How can you reconcile this observation with the cause of death being hypoxia? Students are asked to read through Part I and then spend minutes in small groups discussing whether they believe these respiratiin are linked.

chicago cyanide murders a case study in cellular respiration answers

Students are often interested in the actual case of Tylenol poisoning, and the case can be ended with a discussion about the real-life Tylenol killer. This page can be found at http: In fact, it was developed as a suicide pill called L- pill during World War II so that British and American spies could avoid being captured alive. The reason for the hypoxia is not always clear at the first examination.

chicago cyanide murders a case study in cellular respiration answers

Recall that the mitochondrion is sometimes called the “powerhouse” of the cell.